Analyzing the behaviour of a population in response to disease and interventions is critical to unearth variability in healthcare as well as understand sub-populations that require specialized attention, but also to assist in designing future interventions. Two aspects become very essential in such analysis namely: i) Discovery of differentiating patterns exhibited by sub-populations, and ii) Characterization of the identified subpopulations. For the discovery phase, an array of approaches in the anomalous pattern detection literature have been employed to reveal differentiating patterns, especially to identify anomalous subgroups. However, these techniques are limited to describing the anomalous subgroups and offer little in form of insightful characterization, thereby limiting interpretability and understanding of these data-driven techniques in clinical practices. In this work, we propose an analysis of differentiated output (rather than discovery) and quantify anomalousness similarly to the counter-factual setting. To this end we design an approach to perform post-discovery analysis of anomalous subsets, in which we initially identify the most important features on the anomalousness of the subsets, then by perturbation, the approach seeks to identify the least number of changes necessary to lose anomalousness. Our approach is presented and the evaluation results on the 2019 MarketScan Commercial Claims and Medicare data, show that extra insights can be obtained by extrapolated examination of the identified subgroups.

An automated feature selection pipeline was developed using several state-of-the-art feature selection techniques to select optimal features for Differentiating Patterns of Care (DPOC). The pipeline included three types of feature selection techniques; Filters, Wrappers and Embedded methods to select the top K features. Five different datasets with binary dependent variables were used and their different top K optimal features selected. The selected features were tested in the existing multi-dimensional subset scanning (MDSS) where the most anomalous subpopulations, most anomalous subsets, propensity scores, and effect of measures were recorded to test their performance. This performance was compared with four similar metrics gained after using all covariates in the dataset in the MDSS pipeline. We found out that despite the different feature selection techniques used, the data distribution is key to note when determining the technique to use.

Deep generative models, such as Variational Autoencoders (VAEs), have been employed widely in computational creativity research. However, such models discourage out-of-distribution generation to avoid spurious sample generation, limiting their creativity. Thus, incorporating research on human creativity into generative deep learning techniques presents an opportunity to make their outputs more compelling and human-like. As we see the emergence of generative models directed to creativity research, a need for machine learning-based surrogate metrics to characterize creative output from these models is imperative. We propose group-based subset scanning to quantify, detect, and characterize creative processes by detecting a subset of anomalous node-activations in the hidden layers of generative models. Our experiments on original, typically decoded, and "creatively decoded" (Das et al 2020) image datasets reveal that the proposed subset scores distribution is more useful for detecting creative processes in the activation space rather than the pixel space. Further, we found that creative samples generate larger subsets of anomalies than normal or non-creative samples across datasets. The node activations highlighted during the creative decoding process are different from those responsible for normal sample generation.

This work views neural networks as data generating systems and applies anomalous pattern detection techniques on that data in order to detect when a network is processing an anomalous input. Detecting anomalies is a critical component for multiple machine learning problems including detecting adversarial noise. More broadly, this work is a step towards giving neural networks the ability to recognize an out-of-distribution sample. This is the first work to introduce "Subset Scanning" methods from the anomalous pattern detection domain to the task of detecting anomalous input of neural networks. Subset scanning treats the detection problem as a search for the most anomalous subset of node activations (i.e., highest scoring subset according to non-parametric scan statistics). Mathematical properties of these scoring functions allow the search to be completed in log-linear rather than exponential time while still guaranteeing the most anomalous subset of nodes in the network is identified for a given input. Quantitative results for detecting and characterizing adversarial noise are provided for CIFAR-10 images on a simple convolutional neural network. We observe an "interference" pattern where anomalous activations in shallow layers suppress the activation structure of the original image in deeper layers.

Identifying anomalous patterns in real-world data is essential for understanding where, when, and how systems deviate from their expected dynamics. Yet methods that separately consider the anomalousness of each individual data point have low detection power for subtle, emerging irregularities. Additionally, recent detection techniques based on subset scanning make strong independence assumptions and suffer degraded performance in correlated data. We introduce methods for identifying anomalous patterns in non-iid data by combining Gaussian processes with novel log-likelihood ratio statistic and subset scanning techniques. Our approaches are powerful, interpretable, and can integrate information across multiple data streams. We illustrate their performance on numeric simulations and three open source spatiotemporal datasets of opioid overdose deaths, 311 calls, and storm reports.